Thursday 26 September
Discussion Keynote Chair Plenary Keynote Forum /
Workshop
Exhibitor
[Schedule with Tracks only]
DAY 1The AuditoriumHelix Room 1Helix Room 3DAY 1
DAY 1The AuditoriumHelix Room 1Helix Room 3DAY 1
08:00 Arrival, registration & welcome coffee 08:00
08:05 08:05
08:10 08:10
08:15 08:15
08:20 08:20
08:25 08:25
08:30 08:30
08:35 08:35
08:40 08:40
08:45 08:45
08:50 08:50
08:55 08:55
09:00 Conference Introduction
Chairs: Ned Wakeman, Biohub Alderley 
09:00
09:05 09:05
09:10 Plenary Keynote
Widening the Therapeutic Window: Kinetic Selectivity and Target Vulnerability
09:10 (50 mins)
Prof Peter Tonge, Stony Brook University 
09:10
09:15 09:15
09:20 09:20
09:25 09:25
09:30 09:30
09:35 09:35
09:40 09:40
09:45 09:45
09:50 09:50
09:55 09:55
10:00 Session Chair Introductions
Chairs: Paul Walker, Cyprotex  David Cronk, Charles River Laboratories 
Session Chair Introductions
Chairs: Clive Dilworth, Alderley Park Biohub  Malcolm Haddrick, Catapult 
Session Chair Introductions
Chairs: Geoff Holdgate, AstraZeneca Dr Claire McWhirter, Artiospharma 
10:00
10:05 Imaging techniques in Drug Discovery
Techniques for multiscale fluorescence imaging of 3D in vitro models
10:05 (30 mins)
Mike Shaw, The National Physical Laboratory  
Approaches and technologies to address early safety assessment
SNPing in and out of stem cell-cardiomyocytes with Cas9/CRISPR
10:05 (30 mins)
Prof Chris Denning, University of Nottingham 
Mechanistic Enzymology in Drug Discovery
Resonance energy transfer approaches for measuring enzyme-ligand binding kinetics
10:05 (30 mins)
Prof Steven Charlton, Excellerate Bioscience  
10:05
10:10 10:10
10:15 10:15
10:20 10:20
10:25 10:25
10:30 10:30
10:35 Miltenyi Biotec Ltd
TITLE - Miltenyi Biotec’s MACSima Imaging Platform – Understanding Nature’s Complexity PRESENTER - Supa Coles
Hamilton Bonaduz AG
TITLE - Hamilton Automated Solution - 3D in-vitro Hepatotoxicity Testing PRESENTER - Kate Sanders ABSTRACT - Hamilton has worked with various partners to provide an affordable and reliable automated s...[More]
Enzymlogic
TITLE - Kinetic Selectivity at Scale using KINETICfinder PRESENTER - Jeremy Hague
10:35
10:40 GE Healthcare Life Sciences
TITLE - Optimising High Content Analysis for 3D structures PRESENTER - Mark Graham ABSTRACT - 3D imaging both Spheroids and Organ-on-chip models have increased the requirements of high-content analysi...[More]
INTEGRA Bioscience Ltd
TITLE - Assist Plus PRESENTER - Sharon Barnard ABSTRACT - INTEGRA has developed the revolutionary ASSIST PLUS pipetting robot to streamline routine pipetting tasks at an affordable price. Using INTEGR...[More]
LabLogic Systems Limited
TITLE - Hidex Sense Multi Technology Microplate Reader and InCellis Samrt Cell Imaging System PRESENTER - Lucy Farmer ABSTRACT - The Hidex Sense is the only plate reader on the market that combines li...[More]
10:40
10:45 Coffee Break 10:45
10:50 10:50
10:55 10:55
11:00 11:00
11:05 11:05
11:10 11:10
11:15 11:15
11:20 11:20
11:25 11:25
11:30 Imaging techniques in Drug Discovery
High content 3-D light sheet microscopy in 96 and 384-well plate formats: cancer cell morphology and invasiveness and spheroid-based assays for compound safety screening
11:30 (30 mins)
Christopher Dunsby, Imperial College, London 
Approaches and technologies to address early safety assessment
Translational Models for Drug-Induced Liver Injury: focus on stem cells
11:30 (30 mins)
Prof Chris Goldring, MRC Centre for Drug Safety Science - University of Liverpool 
Mechanistic Enzymology in Drug Discovery
Implementing a High-throughput Matrix Method for Determining Inhibition Modality Post HTS
11:30 (30 mins)
Gareth Davies, AstraZeneca 
11:30
11:35 11:35
11:40 11:40
11:45 11:45
11:50 11:50
11:55 11:55
12:00 Imaging techniques in Drug Discovery
Multimodal, Multiscale Imaging in Drug Discovery
12:00 (30 mins)
Dr Philippa Hart, Medicines Discovery Catapult 
Approaches and technologies to address early safety assessment
De-risking DILI using cellular imaging of in vitro models including 3D liver microtissues
12:00 (30 mins)
Paul Walker, Cyprotex 
Mechanistic Enzymology in Drug Discovery
The rise of high-throughput mass spectrometry for cellular profiling of early drug candidates
12:00 (30 mins)
Martin Bachman, Medicines Discovery Catapult 
12:00
12:05 12:05
12:10 12:10
12:15 12:15
12:20 12:20
12:25 12:25
12:30 Nexcelom Bioscience Ltd
TITLE - Cellaca MX, the high-speed automation ready cell counter and image cytometer PRESENTER - Dr Sun Yung, Field Application Scientist ABSTRACT - Nexcelom Bioscience LLC is a manufacturer of innov...[More]
Cellbox Solutions
TITLE - THE LIVE CELL SHIPPER - A Portable CO2 Incubator to Revolutionize Biopharmaceutical Supply Chain Programs PRESENTER - Mr Corné Swart (PhD) ABSTRACT - Are you tired of massive drawbacks due to ...[More]
Promega UK Ltd
TITLE - Measuring Kinase-Ligand Affinity in Live Cells PRESENTER - Craig Malcolm ABSTRACT - Promega is a world leading supplier of novel cell-based assays to the Pharma-Biotech industry. The NanoBRET™...[More]
12:30
12:35 Poster Spotlight Presentations - Imaging techniques in Drug Discovery
Conjugated polymer nanoparticles: highly fluorescent imaging agents for multiple cellular applications
12:35 (10 mins)
Dr Dermott 0’Callaghan, Stream Bio Ltd 

High-content confocal imaging for exploring fibrosis, immune cell function and receptor trafficking
12:45 (10 mins)
Dr Omar Qureshi, Celentyx 
Poster Spotlight Presentations - Approaches and technologies to address early safety assessment
Using Machine Learning and Artificial Intelligence to Decipher Genotoxic Mechanism of Action
12:35 (10 mins)
Ms Amy Wilson, Astrazeneca 

Development of a multiparametric structural cardiovascular toxicity imaging assay using iPSc derived cardiomyocytes
12:45 (10 mins)
Dr Will Stebbeds, GlaxoSmithKline (GSK) 
Poster Spotlight Presentations - Mechanistic Enzymology in Drug Discovery
Identification of a Novel Small Molecule Inhibitor of the RNA Demethylase FTO using MST
12:35 (10 mins)
Dr Christopher Tomlinson, Sygnature Discovery 

Characterising the kinetic mechanism of Protein Arginine Methyltransferase 5
12:45 (10 mins)
Dr Karl Syson, AstraZeneca 
12:35
12:40 12:40
12:45 12:45
12:50 12:50
12:55 12:55
13:00 Lunch 13:00
13:05 13:05
13:10 13:10
13:15 13:15
13:20 13:20
13:25 13:25
13:30 13:30
13:35 13:35
13:40 13:40
13:45 13:45
13:50 13:50
13:55 13:55
14:00 14:00
14:05 14:05
14:10 14:10
14:15 14:15
14:20 14:20
14:25 14:25
14:30 Imaging techniques in Drug Discovery
Functional ultrasound - novel in-vivo imaging technique for pre-clinical CNS drug discovery
14:30 (30 mins)
Antti Nurmi , Charles River Discovery Services Finland 

Preclinical imaging technologies for assessing drug toxicity and cancer treatment response
15:00 (30 mins)
Dr Harish Poptani, University of Liverpool 
Approaches and technologies to address early safety assessment
Overview of GSK’s approach to early safety assessment
14:30 (30 mins)
Su Moore, GlaxoSmithKline 

Using Data Science and Artificial Intelligence to Improve the Safety of Novel Drugs
15:00 (30 mins)
Dr Nigel Greene, AstraZeneca 
Mechanistic Enzymology in Drug Discovery
Biophysical analysis of tethered enzymatic reactions in surface plasmon resonance with application to the tyrosine phosphatase SHP-1
14:30 (30 mins)
Omer Dushek, University of Oxford 

Mechanics and execution of homologous recombination: a single-molecule view
15:00 (30 mins)
Ondrej Belan, Francis Crick Institute 
14:30
14:35 14:35
14:40 14:40
14:45 14:45
14:50 14:50
14:55 14:55
15:00 15:00
15:05 15:05
15:10 15:10
15:15 15:15
15:20 15:20
15:25 15:25
15:30 Imaging techniques in Drug Discovery
Large multidisciplinary data sets inform advanced therapeutic developments in gynaecological oncology
15:30 (30 mins)
Lewis Francis, University of Swansea 
Approaches and technologies to address early safety assessment
New Models for Human-relevant ADMET Investigations
15:30 (30 mins)
Prof Ian Wilson, Imperial College London 
Mechanistic Enzymology in Drug Discovery
Getting in a Flap with DNA
15:30 (30 mins)
David Finger, University of Sheffield 
15:30
15:35 15:35
15:40 15:40
15:45 15:45
15:50 15:50
15:55 15:55
16:00 Conference close and Networking 16:00
16:05 16:05
16:10 16:10
16:15 16:15
16:20 16:20
16:25 16:25
16:30 16:30
16:35 16:35
16:40 16:40
16:45 16:45
16:50 16:50
16:55 16:55
17:00 17:00
17:05 17:05
17:10 17:10
17:15 17:15
17:20 17:20
17:25 17:25
17:30 17:30
17:35 17:35
17:40 17:40
17:45 17:45
17:50 17:50
17:55 17:55
18:00 18:00