Prof Nicolai Siegel

The Siegel Lab
Infections with seemingly identical pathogens can lead to drastically different outcomes – as seen in the current Corona pandemic. Such differences can be due to host specific factors or caused by cell-to-cell heterogeneity in pathogen populations.

My group aims to elucidate the mechanisms that control cell-to-cell heterogeneity in a population across different scales, i.e. how differences in genome sequence, chromatin organization and 3D genome architecture influence the expression of different surface antigens. A special focus of our work lies on understanding how ncRNA contribute to the organization of the 3D genome architecture and how RNA processing hotspots can serve as ‘post-transcriptional’ enhancers (Müller et al., Nature 2018, Faria et al., Nature Microbiology 2018).
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The Siegel lab is a member of the Faculty of Veterinary Medicine and the Faculty of Medicine at the LMU Munich. We are associated with the Chair of Experimental Parasitology (Markus Meissner) and located at the Chair of Physiological Chemistry (Andreas Ladurner) at the Biomedical Center Munich (BMC).