Abstract

Our mission is to provide services to research groups throughout Sweden, and together identify, validate and use small molecules to explore biology. The Chemical Biology Consortium Sweden (CBCS) (www.cbcs.se) is a national research infrastructure in Sweden funded by the Swedish Research Council, Science for Life Laboratory, and the host universities. The aim of CBCS is to provide world-leading expertise in the field of chemical biology, as well as to strengthen research in chemical biology at a national level. Along this line, CBCS is a core part of the Chemical Biology and Genome Engineering (CBGE) facility at SciLifeLab, which also includes the CRISPR Functional Genomics and Chemical Proteomics platforms. KI and Umeå University were the two initial nodes in the CBCS national infrastructure for research in chemical biology and have been in operation since 2010. Since the beginning of 2022, CBCS has expanded to Linköping (LiU), Uppsala (UU), Lund (LU) and Göteborg (GU), providing local access to most of Sweden. The mission of CBCS is to provide a state-of-the-art platform and expertise for the generation of high-quality bioactive chemical tools for proof-of-concept applications within life science research in general and with the goal to explore complex biology. To do this CBCS provides support to academic researchers in assay development, screening, chemistry, compound profiling, disease profiling, access to compound libraries and analysis. Additionally, CBCS provides access to a high-quality chemical collection (~350 000 compounds) that originates from the pharmaceutical industries and has been developed and expanded with compounds from various commercial vendors. The available screening collections include chemically diverse sets to approved drugs and pharmacological tool compounds. CBCS has well-functioning logistics and routines for distribution of assay ready plates and library compounds nationally.