In this study, it was aimed to compare with cell screening the analgesic and anti-inflammatory effects of safflower oil and compare with benzidamine HCl with experimentally proven naproxen sodium.

 42, 200-250 gr Wistar-albino species healthy adult female rats were separated in six groups so as to be seven randomised rats in each group, then experimental pain is formed and peripheral and central analgesic efficacy were evaluated. Second stage is performed with total of four groups with seven randomised rats in each. To create experimental inflammation, 2% formaldehyde injection was applied to rat paw and oedema in the paw was measured and recorded for ten days. Oedema inhibition was calculated as percentage. Then paws and stomachs of the put down rats were dissected and examined histo-pathologically for cell screening. All obtained data were compared statistically; by performing Shapiro Wilk test, Kruskal-Wallis H test and two directional variance analysis. 

In our study, when cell screening of rat stomachs was performed, cell infiltration, edema, venous congestion, and epithelial damage levels in the safflower oil group were determined to be lower than in the placebo group. This difference, that is, lower epithelial damage in the safflower oil group versus the naproxen sodium group, was found to be statistically significant. Drug industry continuously performs studies to find molecules that have stronger efficacy in shorter timer periods. Since removal of pain and inflammation is at the forefront of most diseases, studies to find new molecules and combinations that have high analgesic and anti-inflammatory efficacy, lower side effect incidence continues.