Abstract

Advances in cellular models are enabling the generation of more disease relevant data for drug discovery. In order for these models to be utilised for high-throughput drug screening and profiing, there is a need for the miniaturisation and automation of complex cell-based assays. We have designed and built integrated robotics platforms for the automation of a range of advanced cellular assays. These platforms will increase the throughput of these complex assays, enable kinetic sampling, ensure accurate timing control of critical experimental steps and reduce resource burden. When combined with multiparametric readouts, these automated screens can provide a wealth of disease relevant data for the drug discovery field.