Objective

Kinetic and mechanistic in-vitro characterization (the “Fourth Dimension”) yields critical predictive information on compounds’ potency in cellular assays, their DMPK profile, and their in-vivo performance. Thus, the ability to characterize more compounds this way in early SAR screening holds substantial benefit. Scalable instrumentation and lab automation to this end is available now. However, the complex data analysis easily takes a day per experiment, severely limiting throughput.

This poster outlines recent advances in data analysis procedures to match the recent progress in developing rapid plate based kinetic techniques. A new software solution reduces analysis times ten-fold, while ensuring scalable, consistent, reliable data processing of biophysical and mechanistic assays and direct publishing of results to a corporate level for the effective ranking of lead series. With this new approach, we aim to dramatically scale up compound characterization embedded in a streamlined and modern pharma research workflow.