Objective

RNAi (and more recently CRISPR) screens give rise to a wealth of genome-scale information on gene function. Frequently, however, published analysis is mostly focussed on a few top-scoring genes.  Furthermore, published screening data is rarely exploited by other groups.  Phenovault is a growing database and analysis suite hosted by siTOOLs Biotech, aimed at making best use of existing screening datasets.  It currently contains more data than any existing RNAi screening repository.  Importantly, by emphasising the seed-based effect as a major contributor to phenotypes, Phenovault provides a new and normally disregarded perspective on RNAi screens.  Beyond serving as a rich source of well-structured, open-access screening data, Phenovault provides advanced analyses of screening datasets, using public and proprietary hit-detection algorithms (on-target and seed-based). As such, Phenovault will assist both screeners and target-focussed researchers to access the treasures lurking in supplementary data and unnoticed publications.