BSP Spring Meeting 2019
Schedule : Back to Prof Matthew Higgins

How does the African trypanosome surface mediate its interaction with its mammalian host?

Mon15  Apr04:15pm(30 mins)
Renold C16
Keynote Speaker:
Prof Matthew  Higgins


M Higgins1
1 Oxford University, UK


The surfaces of the African trypanosomes are the interfaces between host and parasite. They are coated with a dense layer of variant surface glycoproteins, allowing a population of parasites to use mechanisms of antigenic variation to persist despite the attack of the mammalian immune system. Within this layer operate receptors which are used by the trypanosomes to scavenge nutrients and are exploited by human innate immunity as a route for lytic factor uptake. This talk will present our recent structural insights into how these receptors bind to their ligands and how they have evolved to avoid the mammalian immune defences.

Hosted By

British Society for Parasitology (BSP)

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