R Francoeur1; A Wamoko2; P H Lamberton1;
1 Institute of Biodiversity, Animal Health and comparative Medicine, and Wellcome Centre for Parasitology, University of Glasgow, UK; 2 Vector Control Division, Ministry of Health, Republic of Uganda, Uganda
malaria are the two most significant human parasitic diseases. Schistosomiasis is
a commonly occurring neglected tropical disease with over 240million people infected
globally. In 2016, there were 216 million cases of malaria worldwide resulting
in an estimated 731,000 deaths. Praziquantel is the standard chemotherapeutant in
treating schistosomiasis however, in certain endemic hotspots, despite over a
decade of mass drug administration (MDA), infection intensities and prevalence remain
higher. Past studies indicate a
correlation between increased risk of malaria contraction in individuals with
schistosomiasis. However, it is unknown if malarial infections play a role in
susceptibility to reinfection with schistosomiasis, nor whether drug efficacy
is influenced. This study investigates the impact of malaria coinfections on Schistosoma mansoni includinginfection intensity, clearance post
treatment, and reinfection rates.Samples
were obtained from 197 school children aged 6-14 in the Mayuge district of
Uganda who were tested for S. mansoni
and Plasmodium falciparum. Infection
data were obtained using Kato-Katz for S.
mansoni egg counts and RDT tests for P.
falciparum. Results from regression analysis will be presented on
correlations between co-infected individuals, clearance, and reinfection rates
compared with those infected with only S.
mansoni. These results will
contribute to a broader biostatistical study looking at host factors that
influence S. mansoni clearance.