ELRIG
Drug Discovery 2015
Wednesday, 2 Sep 2015 to Thursday, 3 Sep 2015
Drug Discovery 2015
Overview
General Info
Speakers
Presentations
Programme
Posters
Exhibitors
Delegates
Forum
Wednesday 2 September
3 September
Presentation Keynote Chair Plenary Keynote Forum /
Workshop
Exhibitor
DAY 1Exhibition AreaPattingham
Metabolic & Cardiovascular Drug Discovery
Beckbury
Chemistry Innovation in Lead Discovery
Wenlock
Target Identification & Validation
Ironbridge
Innovation in Assay Development & Screening
Coalport
Workshop
Jackfield
DAY 2
DAY 1Exhibition AreaPattingham
Metabolic & Cardiovascular Drug Discovery
Beckbury
Chemistry Innovation in Lead Discovery
Wenlock
Target Identification & Validation
Ironbridge
Innovation in Assay Development & Screening
Coalport
Workshop
Jackfield
DAY 2
08:00 Arrival, Registration & Coffee 08:00
08:05 08:05
08:10 08:10
08:15 08:15
08:20 08:20
08:25 08:25
08:30 08:30
08:35 08:35
08:40 08:40
08:45 08:45
08:50 08:50
08:55 08:55
09:00 09:00
09:05 09:05
09:10 Session Chair Introduction
Chairs: Dr Darren McKerrecher, AstraZeneca  Paul Wyatt, University of Dundee 
Session Chair Introduction
Chairs: Prof Michael Schneider, Imperial College London Dr Marcus Schindler, AstraZeneca R&D Mölndal 
Session Chair Introduction
Chairs: Rachel Grimley, AstraZeneca  Jon Moore, Horizon Discovery 
Session Chair Introduction
Chairs: Steve Hill, University of Nottingham  Anne Phelan, Pfizer Neusentis 
09:10
09:15 Using Diversity-Oriented Synthesis to Enable Fragment-Based Lead Discovery
Keynote Speaker: Damian Young, Baylor College of Medicine 
Myocyte Lipotoxicity: A Chemical Biology Approach
Keynote Speaker: Daniel P. Kelly, Sanford Burnham Prebys Medical Discovery Institute 
Target Identification and Target Engagement: Applications in Drug Discovery
Keynote Speaker: Friedrich Reinhard, Cellzome, a GSK company 
Phenotypic Screening for Novel Druggable Targets Using "Protein-Interference"
Keynote Speaker: Chris Torrance, PhoreMost Ltd 
09:15
09:20 09:20
09:25 09:25
09:30 09:30
09:35 09:35
09:40 09:40
09:45 09:45
09:50 09:50
09:55 09:55
10:00 Nanotechnology, Imaging and Targeted Drug Therapy in Cardiac Pathology
Kim Kelly, University of Virginia 
Design of Novel Building Blocks to Enhance Drug Discovery
Dr Frederick Goldberg, AstraZeneca 
The Role of Systems Biology / Pharmacology in Choosing and Validating Targets
Neil Benson, Xenologiq 
The Kinetics of Drug-Receptor Binding: Why It Is Important and How We Can Measure It
Steven Charlton, University of Nottingham 
10:00
10:05 10:05
10:10 10:10
10:15 10:15
10:20 10:20
10:25 10:25
10:30 Coffee Break 10:30
10:35 10:35
10:40 10:40
10:45 10:45
10:50 10:50
10:55 10:55
11:00 Novel Inhibitors of MAP4K4 (HGK), an Acute Therapy to Prevent Cardiac Muscle Cell Death Following Myocardial Infarction
Katie Chapman, Domainex 
Phenotypic Drug Discovery: With A Lot of Help From Our Friends!
Paul Wyatt, University of Dundee 
Mass Spectrometry-Based Discovery Tools for Epigenetics
Pete DiMaggio, Imperial College London 
Biased Ligand Quantification in Drug Discovery: From Theory to High Throughput Screening to Identify New Biased µ Opioid Receptor Agonists
David Winpenny, Pfizer Neusentis 
11:00
11:05 11:05
11:10 11:10
11:15 11:15
11:20 11:20
11:25 11:25
11:30 Poster Tasters
Poster Tasters
Poster Tasters
Poster Tasters
11:30
11:35 11:35
11:40 11:40
11:45 11:45
11:50 11:50
11:55 11:55
12:00 Snapshot Presentations
Session: Metabolic & Cardiovascular Drug Discovery
Snapshot Presentations
Session: Chemistry Innovation in Lead Discovery
Snapshot Presentations
Session: Target Identification & Validation
Snapshot Presentations
Session: Innovation in Assay Development & Screening
12:00
12:05 12:05
12:10 12:10
12:15 12:15
12:20 12:20
12:25 12:25
12:30 Lunch - Exhibition - Posters - Workshops 1230hrs - 1350hrs 12:30
12:35 12:35
12:40 12:40
12:45 12:45
12:50 12:50
12:55 12:55
13:00 13:00
13:05 13:05
13:10 13:10
13:15 13:15
13:20 13:20
13:25 13:25
13:30 13:30
13:35 13:35
13:40 13:40
13:45 13:45
13:50 Welcome Words from the Chairman
Chairs: Sanj Kumar, ELRIG 
13:50
13:55 13:55
14:00 Tackling Protein Trafficking Diseases
David Thomas, Traffick Therapeutiques, Inc 
14:00
14:05 14:05
14:10 14:10
14:15 14:15
14:20 14:20
14:25 14:25
14:30 14:30
14:35 14:35
14:40 14:40
14:45 14:45
14:50 14:50
14:55 14:55
15:00 Unravelling the Molecular Mechanisms of Proteinuria
Tobias Huber, University of Freiburg 
Structure-Kinetic Relationships: Investigating the Molecular Basis for Optimising Drug-Target Residence Time
Dr Mike Waring, AstraZeneca  
The Impact of CRISPR/Cas9 on Target Identification and Validation
Jon Moore, Horizon Discovery 
Efficacy and Toxicity Assays Using iPS cells - Utilising Cells Reset to the Manufacturers Default Setting
Julie Holder, Roslin Cells 
15:00
15:05 15:05
15:10 15:10
15:15 15:15
15:20 15:20
15:25 15:25
15:30 Synthetic Chemically modified mRNA (modRNA): Towards A New Technology Platform for Cardiovascular Biology and Medicine
Ken Chien, Karolinska Instituet 
All in Good Time, Exploiting Residence Time to Improve Fragment Based Drug Discovery
James Murray , Vernalis (R&D) Ltd 
The Application of Synthetic Lethality to Cancer Treatment
Chris Lord, Institute of Cancer Research 
Functional Screening of Network Activity in Primary Neuronal Cultures Using a Novel Phenotypic Assay Platform
Mattias Karlsson, Cellectricon AB 
15:30
15:35 15:35
15:40 15:40
15:45 15:45
15:50 15:50
15:55 15:55
16:00 The Role of Post-Transcriptional Regulation in Cardiac Disease
Norbert Hübner, Max-Delbrück-Center for Molecular Medicine (MDC) 
Phage Selection of Bicyclic Peptides for Therapeutic Application
Christian Heinis, Ecole Polytechnique Fédérale de Lausanne (EPFL) 
New Targets for Virus-Induced Asthma Exacerbations: From Bedside to Bench
Michael Edwards, Imperial College London 
Nanobodies in Cell-Based Screening
Miguel Conde, Ablynx 
16:00
16:05 16:05
16:10 16:10
16:15 16:15
16:20 16:20
16:25 16:25
16:30 Poster Session 16:30
16:35 16:35
16:40 16:40
16:45 16:45
16:50 16:50
16:55 16:55
17:00 Posters - Networking - Drinks Reception 17:00
17:05 17:05
17:10 17:10
17:15 17:15
17:20 17:20
17:25 17:25
17:30 17:30
17:35 17:35
17:40 17:40
17:45 17:45
17:50 17:50
17:55 17:55
18:00 18:00
18:05 18:05
18:10 18:10
18:15 18:15
18:20 18:20
18:25 18:25
18:30 18:30
18:35 18:35
18:40 18:40
18:45 18:45
18:50 18:50
18:55 18:55
19:00 19:00