Wednesday 2 September
3 September
Presentation Keynote Chair Plenary Keynote Forum /
Workshop
Exhibitor
DAY 1Exhibition AreaPattingham
Metabolic & Cardiovascular Drug Discovery
Beckbury
Chemistry Innovation in Lead Discovery
Wenlock
Target Identification & Validation
Ironbridge
Innovation in Assay Development & Screening
Jackfield
DAY 2
DAY 1Exhibition AreaPattingham
Metabolic & Cardiovascular Drug Discovery
Beckbury
Chemistry Innovation in Lead Discovery
Wenlock
Target Identification & Validation
Ironbridge
Innovation in Assay Development & Screening
Jackfield
DAY 2
08:00 Arrival, Registration & Coffee 08:00
08:05 08:05
08:10 08:10
08:15 08:15
08:20 08:20
08:25 08:25
08:30 08:30
08:35 08:35
08:40 08:40
08:45 08:45
08:50 08:50
08:55 08:55
09:00 09:00
09:05 09:05
09:10 Session Chair Introduction
Chairs: Dr Darren McKerrecher, AstraZeneca  Paul Wyatt, University of Dundee 
Session Chair Introduction
Chairs: Prof Michael Schneider, Imperial College London Dr Marcus Schindler, AstraZeneca R&D Mölndal 
Session Chair Introduction
Chairs: Rachel Grimley, AstraZeneca  Jon Moore, Horizon Discovery 
Session Chair Introduction
Chairs: Steve Hill, University of Nottingham  Anne Phelan, Pfizer Neusentis 
09:10
09:15 Using Diversity-Oriented Synthesis to Enable Fragment-Based Lead Discovery
09:15 (45 mins)
Keynote Speaker: Damian Young, Baylor College of Medicine 
Myocyte Lipotoxicity: A Chemical Biology Approach
09:15 (45 mins)
Keynote Speaker: Daniel P. Kelly, Sanford Burnham Prebys Medical Discovery Institute 
Target Identification and Target Engagement: Applications in Drug Discovery
09:15 (45 mins)
Keynote Speaker: Friedrich Reinhard, Cellzome, a GSK company 
Phenotypic Screening for Novel Druggable Targets Using "Protein-Interference"
09:15 (45 mins)
Keynote Speaker: Chris Torrance, PhoreMost Ltd 
09:15
09:20 09:20
09:25 09:25
09:30 09:30
09:35 09:35
09:40 09:40
09:45 09:45
09:50 09:50
09:55 09:55
10:00 Nanotechnology, Imaging and Targeted Drug Therapy in Cardiac Pathology
10:00 (30 mins)
Kim Kelly, University of Virginia 
Design of Novel Building Blocks to Enhance Drug Discovery
10:00 (30 mins)
Dr Frederick Goldberg, AstraZeneca 
The Role of Systems Biology / Pharmacology in Choosing and Validating Targets
10:00 (30 mins)
Neil Benson, Xenologiq 
The Kinetics of Drug-Receptor Binding: Why It Is Important and How We Can Measure It
10:00 (30 mins)
Steven Charlton, University of Nottingham 
10:00
10:05 10:05
10:10 10:10
10:15 10:15
10:20 10:20
10:25 10:25
10:30 Coffee Break 10:30
10:35 10:35
10:40 10:40
10:45 10:45
10:50 10:50
10:55 10:55
11:00 Novel Inhibitors of MAP4K4 (HGK), an Acute Therapy to Prevent Cardiac Muscle Cell Death Following Myocardial Infarction
11:00 (30 mins)
Katie Chapman, Domainex 
Phenotypic Drug Discovery: With A Lot of Help From Our Friends!
11:00 (30 mins)
Paul Wyatt, University of Dundee 
Mass Spectrometry-Based Discovery Tools for Epigenetics
11:00 (30 mins)
Pete DiMaggio, Imperial College London 
Biased Ligand Quantification in Drug Discovery: From Theory to High Throughput Screening to Identify New Biased µ Opioid Receptor Agonists
11:00 (30 mins)
David Winpenny, Pfizer Neusentis 
11:00
11:05 11:05
11:10 11:10
11:15 11:15
11:20 11:20
11:25 11:25
11:30 Poster Tasters
Poster Tasters
Poster Tasters
Poster Tasters
11:30
11:35 11:35
11:40 11:40
11:45 11:45
11:50 11:50
11:55 11:55
12:00 Snapshot Presentations
Session: Metabolic & Cardiovascular Drug Discovery
Snapshot Presentations
Session: Chemistry Innovation in Lead Discovery
Snapshot Presentations
Session: Target Identification & Validation
Snapshot Presentations
Session: Innovation in Assay Development & Screening
12:00
12:05 12:05
12:10 12:10
12:15 12:15
12:20 12:20
12:25 12:25
12:30 Lunch - Exhibition - Posters - Workshops 1230hrs - 1350hrs 12:30
12:35 12:35
12:40 12:40
12:45 12:45
12:50 12:50
12:55 12:55
13:00 13:00
13:05 13:05
13:10 13:10
13:15 13:15
13:20 13:20
13:25 13:25
13:30 13:30
13:35 13:35
13:40 13:40
13:45 13:45
13:50 Welcome Words from the Chairman
Chairs: Sanj Kumar, ELRIG 
13:50
13:55 13:55
14:00 Tackling Protein Trafficking Diseases
14:00 (60 mins)
David Thomas, Traffick Therapeutiques, Inc 
14:00
14:05 14:05
14:10 14:10
14:15 14:15
14:20 14:20
14:25 14:25
14:30 14:30
14:35 14:35
14:40 14:40
14:45 14:45
14:50 14:50
14:55 14:55
15:00 Unravelling the Molecular Mechanisms of Proteinuria
15:00 (30 mins)
Tobias Huber, University of Freiburg 
Structure-Kinetic Relationships: Investigating the Molecular Basis for Optimising Drug-Target Residence Time
15:00 (30 mins)
Dr Mike Waring, AstraZeneca  
The Impact of CRISPR/Cas9 on Target Identification and Validation
15:00 (30 mins)
Jon Moore, Horizon Discovery 
Efficacy and Toxicity Assays Using iPS cells - Utilising Cells Reset to the Manufacturers Default Setting
15:00 (30 mins)
Julie Holder, Roslin Cells 
15:00
15:05 15:05
15:10 15:10
15:15 15:15
15:20 15:20
15:25 15:25
15:30 Synthetic Chemically modified mRNA (modRNA): Towards A New Technology Platform for Cardiovascular Biology and Medicine
15:30 (30 mins)
Ken Chien, Karolinska Instituet 
All in Good Time, Exploiting Residence Time to Improve Fragment Based Drug Discovery
15:30 (30 mins)
James Murray , Vernalis (R&D) Ltd 
The Application of Synthetic Lethality to Cancer Treatment
15:30 (30 mins)
Chris Lord, Institute of Cancer Research 
Functional Screening of Network Activity in Primary Neuronal Cultures Using a Novel Phenotypic Assay Platform
15:30 (30 mins)
Mattias Karlsson, Cellectricon AB 
15:30
15:35 15:35
15:40 15:40
15:45 15:45
15:50 15:50
15:55 15:55
16:00 The Role of Post-Transcriptional Regulation in Cardiac Disease
16:00 (30 mins)
Norbert Hübner, Max-Delbrück-Center for Molecular Medicine (MDC) 
Phage Selection of Bicyclic Peptides for Therapeutic Application
16:00 (30 mins)
Christian Heinis, Ecole Polytechnique Fédérale de Lausanne (EPFL) 
New Targets for Virus-Induced Asthma Exacerbations: From Bedside to Bench
16:00 (30 mins)
Michael Edwards, Imperial College London 
Nanobodies in Cell-Based Screening
16:00 (30 mins)
Miguel Conde, Ablynx 
16:00
16:05 16:05
16:10 16:10
16:15 16:15
16:20 16:20
16:25 16:25
16:30 Poster Session 16:30
16:35 16:35
16:40 16:40
16:45 16:45
16:50 16:50
16:55 16:55
17:00 Posters - Networking - Drinks Reception 17:00
17:05 17:05
17:10 17:10
17:15 17:15
17:20 17:20
17:25 17:25
17:30 17:30
17:35 17:35
17:40 17:40
17:45 17:45
17:50 17:50
17:55 17:55
18:00 18:00
18:05 18:05
18:10 18:10
18:15 18:15
18:20 18:20
18:25 18:25
18:30 18:30
18:35 18:35
18:40 18:40
18:45 18:45
18:50 18:50
18:55 18:55
19:00 19:00