Profile of Prof Jan Bradley
Work in this laboratory focuses on the host-parasite relationship in nematode infections. To be infected with worms is the norm for children in developing countries and helminth infections are also common in vertebrate wildlife populations. Thus, the vertebrate immune system probably evolved in the presence of worm infection and may operate optimally in this context. Helminths are known to polarize the immune response towards Th2 responses, epitomized by high levels of IgE and eosinophilia. They have also recently been shown to induce the development of regulatory T cells. Our work can be divided into the following areas, all of which revolve around defining how the parasite affects and interacts with the host immune system.