Dr Annette MacLeod

Dr Annette MacLeod
Dr Annette MacLeod
Wellcome Senior Fellow
University of Glasgow
Speaker

Presentations at BSP Spring Meeting 2018

Mon9  Apr04:15pm(90 mins)
Chairing

Session: Tryps & Leish Therapeutics, diagnostics & epidemiology II- Sponsored by Elsvier
Room: Stream 1 - Edward Llwyd 0.26 Biology Main
Wed11  Apr11:45am(45 mins)
Keynote: Trypanosomes get under your skin

Session: Wright Medal Lecture
Room: Great Hall, Arts Centre

Profile of Dr Annette MacLeod

I work on single-celled parasites called African trypanosomes. African trypanosomes present a significant burden to large areas of sub-Saharan Africa, leading to an estimated $1.3 billion annual loss to the African economy. The majority of this economic cost is attributable to the veterinary disease Nagana, caused by the animal trypanosome species T. vivax, T. congolense and T. b. brucei. Nagana affects over 20 million livestock animals, lowering herd productivity and increasing mortality. This renders large areas of sub-Saharan Africa inhospitable for the more profitable livestock species and breeds. More directly, in humans, African trypanosomes cause the debilitating and often fatal disease African sleeping sickness, leading to a loss of 1.3 million disability-adjusted life years (DALY) to the African economy annually. The majority of trypanosome species are unable to infect humans due to an innate resistance mechanism. However, the T. brucei subspecies T. b. rhodesiense and T. b. gambiense have evolved to overcome this innate resistance and can infect humans. Of the two human-infective subspecies, T. b. gambiense is the more prevalent, causing more than 95% of human cases.

My research, funded by my Wellcome Trust senior fellowship, is focused on studying two main aspects of T.b. gambiense infections.

1. How the parasites cause infection?
2. How humans fight that infection?

I have also founded an international collaborative research network called TrypanoGEN. Funded by the Wellcome Trust as part of the H3Africa initiative, the overall aim of TrypanoGEN is to improve the health of people living in some of the poorest countries in the world which carry a disproportionate burden of infectious diseases. Despite their importance, the study of many tropical diseases has lagged behind that of diseases of developed countries. The TrypanoGEN network is redressing the balance by performing high quality research into human African trypanosomiasis. The data generated by this network will extend beyond trypanosomiasis susceptibility by providing a unique resource to study human genetic variation across Africa.

TrypanoGEN has 4 main aims:

1 Generate a database of human genetic variation in different African countries and perform a genome-wide association study for susceptibility to trypanosomiasis.
2 Create an extensive biobank housed in network hubs.
3. Develop infrastructure in African laboratories.
4. Provide training for African scientists.

More details about TrypanoGEN can be found at www.trypanogen.net

Colleagues

Alfayez
Delegate
Poster Presenter
Mr Ibrahim Alfayez
PhD student
University of Glasgow
Alpizar Sosa
Delegate
Mr EduBiel Alpizar Sosa
PhD
University of Glasgow
Alpizar Sosa
Delegate
Poster Presenter
Mr EduBiel Alpizar Sosa
DVM, PhD
University of Glasgow
Britton
Delegate
Speaker
Dr Collette Britton
University Reader
University of Glasgow
Campagnaro
Delegate
Mr Gustavo Campagnaro
PhD student
University of Glasgow
Campagnaro
Delegate
Poster Presenter
Mr Gustavo Campagnaro
PhD student
University of Glasgow
Carruthers
Miss Lauren Carruthers
PhD Research Student
University of Glasgow
Carruthers
Delegate
Speaker
Miss Lauren Carruthers
PhD Research Student
University of Glasgow
Champion
Delegate
Poster Presenter
Miss Teteh Champion
PhD student
University of Glasgow
Giordani
Delegate
Dr Federica Giordani
Research assistant
University of Glasgow
Giordani
Speaker
Dr Federica Giordani
Research assistant
University of Glasgow
Gould
Delegate
Dr Matthew Gould
Postdoc
University of Glasgow
Hanks
Speaker
Mrs Eve Hanks
PhD student
University of Glasgow
Hochstetter
Delegate
Dr Axel Hochstetter
Honorary Research Associate
University of Glasgow
Hochstetter
Speaker
Dr. Axel Hochstetter
Honorary Research Associate
University of Glasgow
LinkedIn
Lacombe
Delegate
Speaker
Miss Alice Lacombe
PhD student
University of Glasgow
LinkedIn
Lamberton
Delegate
Dr Poppy Lamberton
Senior Lecturer
University of Glasgow
Llewellyn
Delegate
Mr Martin Llewellyn
Sr Lecturer
University of Glasgow
Schwabl
Delegate
Speaker
Mr Philipp Schwabl
cruzi repro
University of Glasgow
Trienekens
Delegate
Poster Presenter
Ms Suzan Trienekens
PhD Student
University of Glasgow
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