The aim of the meeting will be to discuss molecular and structural principles of nuclear pore organisation, together with new experimental approaches, mechanisms, and models for nuclear transport. We hope to bring together scientists interested in diverse areas of nuclear pore, transport, lamina, organisation and evolution research to stimulate communication and efficient exchange of experimental results, methodology, concepts, and hypotheses.
In the past two decades, our understanding of the nuclear envelope (NE) has been radically transformed. From being viewed as a simple membrane barrier with a lamin intermediate filament lining, the NE is now known to incorporate a signaling and regulatory interface as complex and dynamic as that of the plasma membrane. On the outer face of the NE, connections to cytoskeletal filaments direct cell and nuclear migration and mechanosignal transduction, whilst connections to chromatin on its inner face direct genome regulation and stability. The importance of these various roles is highlighted by the association of NE protein mutations with human diseases ranging from muscular dystrophies to neuropathies, lipodystrophies and premature ageing syndromes.
Additionally, emerging technologies are finally enabling the tackling of longstanding questions such as the higher-order structure of the lamin polymer, nuclear membrane synthesis and dynamics, and membrane protein complexes. Many ER proteins are also now being found to contribute to NE dynamics and investigations of pathogen interactions with the NE are yielding yet further insights into this complex structure. This incredible diversity of functions and structure-function relationships underscores the pleiotropy of NE-linked diseases and in this programme we draw upon experts in biophysics, biochemistry, cell biology, microscopy, and virology to highlight the wide breadth of NE functions. By bringing together diverse groups covering a wide range of expertise, from fluorescence fluxuation microscopy to crosslinking mass spectrometry to human genetics, we expect to promote a dialogue that may better elucidate NE disease mechanisms.
▪ New directions in nuclear envelopathies
▪ Dynamic nucleo-cytoskeletal interactions and mechanotranduction
▪ Genome regulation from the nuclear envelope
▪ New nuclear envelope signaling pathways and mechanisms
▪ Detailed structure of the lamina and membrane complexes
▪ Nuclear membrane biosynthesis and dynamics
▪ Pathogen interactions with the nuclear membrane
Attendance is through invitation.
REGISTRATION AND PAYMENT
We are arranging the meeting as an ad hoc event, and require a deposit to secure the venue and the prices we have negotiated at eight months prior to the meeting, i.e. 24th January.
Provision rates and what is included are as follows (includes sales tax):
-Single room: £580,
-Double room, single occupancy: £735,
-Double room, double occupancy (accompanying person): £785 (+£160 if joining for dinners).
Please note that the hotel could only reserve 17 single rooms at the lower rate; thus these will have to be distributed either on a first-come-first-serve basis or based on need if a financial case can be made in advance.
The package includes: Five nights accommodation, full board (minus one dinner), coffee/refreshments at breaks and access to full hotel facilities.
Accompanying person in room sharing with paying participant will be entitled to: As participant without attendance at scientific sessions or lunch.
These prices are approximate, and may go down with sponsorship, down more (Brexit) or collapse completely (Brexit).
Additional suppers, lunches and other services can be of course be purchased, as can additional nights at the hotel prior to or after the meeting. These need to be negotiated direct with the hotel, but there is a preferential rate for delegates.
The excursions and gin tasting will be on a pay as you go basis.
Payment deadline is the 31st of May
Venue: Peebles Hydro
Country: United Kingdom
Organiser Contact Details:
T: 01234 firstname.lastname@example.org