| DAY 1 | Platinum Suite 1 | Platinum Suite 2 | Platinum Suite 3 | Platinum Suite 4 | Platinum Suite 5 | DAY 1 | Platinum Suite 6 | Platinum Suite 7 | Career Zone | Training Zone |
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| 8:00 | Conference Registration | 8:00 | 8:00: | ||||||||||
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| 8:20: | 8:20: | CamBioScience hands-on training courses overview 08:20 (25 mins) Find out about the various topics, locations, and instructors. You can join the priority list for our future editions and suggest new topics via our online form accessible from your wifi device on the day. - DD18 competition to win a free ticket at our next conference: Share the conference page on social media using the conference hashtag revealed on the day. The most interactive post will win a free ticket to our “Development of the Dopaminergic System: From Stem Cells to Circuits” conference held in Crete on 13-14-15 May 2019. The competition starts on the first day of DD18 and end on Christmas Day. |
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| 8:35: | Innovations in biochemical and biophysical hit finding techniques Chairs: Cara Hall, Bio-Rad Platinum Suite 5 |
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| 8:45: | ELRIG Annual Review 08:45 (15 mins) Steve Rees - ELRIG Chairman |
8:45: | Come chat to us 08:45 (90 mins) We will discuss your training requirements, share resources, and you can join the priority lists for any of our future courses. Have an idea for a particular training course, just come to the training zone to start a collaboration. |
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| 9:00 | Conference & Plenary Keynote Introduction 09:00 (15 mins) Rachel Grimley- AstraZeneca |
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| 9:15: | Plenary Keynote - Day 1 Platinum Suite 1 Drug repurposing for ageing research 09:15 (45 mins) Janet Thornton, European Bioinformatics Institute |
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| 10:15 | Coffee | 10:15 | How to create and take personalised training courses online thanks to Artificial Intelligence 10:15 (35 mins) |
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| 10:45 | 10:45 | Sartorius Stedim Biotech Workshop
Live-cell analysis techniques: developing translational assays for drug discovery 10:45 (5 mins) Translational assays provide critical bridges between in vitro models and the clinic, enabling a greater understanding of disease and potential therapy. To meet these requirements has resulted in an increased employment of more complex and advanced cell models, including co-culture systems, primary/iPSC-derived cells and patient specific tissue organoids. This raises the bar for assay development and functional profiling methods that are able to extract the deeper content provided by these models, whilst maintaining throughput and ease of use. In this workshop, we will discuss the latest developments in live-cell analysis. Through BioTech and CRO end-user case study presentations, new applications in therapeutic discovery projects will be reviewed. These include immune cell killing assays in 2D & 3D, phagocytosis, antibody internalization measurements and tumour-spheroid analyses. Interactive discussions will be encouraged to explore how live-cell analysis is best aligned with discovery project requirements and how they can be further developed to address unmet need. The workshop is targeted toward researchers with general interest in translational cell models, cell-based assays, cancer biology and immunology, including current and prospective users. |
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| 10:50 | Session Chair Introductions 10:50 (10 mins) Martin Swarbrick (CRUK TDL) & Nicole Hamblin (Charles River) |
Session Chair Introductions 10:50 (10 mins) Eddy Stevens (Ario Pharma) & Mark Slack (Evotec) |
Session Chair Introductions 10:50 (10 mins) David Brown (Healx Ltd) & Chris Dowson (Warwick University) |
Session Chair Introductions 10:50 (10 mins) Sarah Nickolls (GSK) & David Kendall (Pharmnovo) |
10:50 | Welcome & introductions 10:50 (5 mins) Tim Dale - Sartorius |
Biohub - " Building Biotech Success: A Practical Case Study with CROs at Alderley Park" 10:50 (70 mins) Presenting: • Blueberry Therapeutics - Dave Cook • Apconix - Ruth Roberts • Aptus Clinical - Steve McConchie • Alderley Park Accelerator (BioHub) - Ned Wakeman |
Short live introduction to Organoid technology. 10:50 (100 mins) Digital lecture on “Cerebral Organoids” on our AI-Learning platform OBRIZUM®, by world-leading expert in the field, Dr Madeline Lancaster (University of Cambridge) - followed by “Check your knowledge” interactive session!By taking part, you can win a free ticket to attend our upcoming 2-Day Hands-On “Cerebral Organoids: Establishment, Culture & Manipulation” Course on 22-23 October 2018 at Homerton College, Cambridge UK. Dr Madeline Lancaster and her lab will be your instructors! |
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| 10:55 | 10:55 | Kinetic measurements of immune cell cytotoxicity 10:55 (25 mins) Dan Foxler - GammaDelta Therapeutics |
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| 11:00 | Chemistry Innovations Platinum Suite 1 Highly potent and selective tumour targeting bicyclic peptides - a novel approach to cancer therapy 11:00 (30 mins) Gemma Mudd, Bicycle Therapeutics |
Innovations in cellular HTS and compound profiling Platinum Suite 2 Using Single Cell Sequencing for Drug discovery 11:00 (30 mins) Martin Guilliams, VIB institute for inflammation |
Anti-infectives & Rare Diseases Platinum Suite 3 Using AI to accelerate combinations drug discovery for rare diseases 11:00 (30 mins) Michale Bouskila-Chubb, Healx Ltd |
BPS Session Platinum Suite 4 Ligand bias at opioid receptors - what is it good for? 11:00 (30 mins) Eamonn Kelly, University of Bristol Neuro-immune interactions and novel targets for chronic pain 11:30 (30 mins) Marzia Malcangio, Kings College London Targeting the reward system in addiction – structure-based drug design of selective orexin 1 receptor antagonist 12:00 (30 mins) Kirstie Bennett, Heptares Therapeutics |
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| 11:20 | 11:20 | Live cell imaging assays for Immuno-oncology drug screening 11:20 (25 mins) Jessy Cartier - Aquila BioMedical |
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| 11:30 | Poster Spotlight - Poster 45 - Thomas Christott 11:30 (15 mins) Development of a chemical probe for the YEATS domains of MLLT1 and MLLT3 |
Poster Spotlight - Poster 55 - Rasel Al-Amin 11:30 (15 mins) Target Engagement-Mediated Amplification for Monitoring Drug-Target Interactions in Situ |
Poster Spotlight - Poster 62 - Dr Clio Andreae 11:30 (15 mins) Tracking bacterial infection and treatment in Galleria mellonella using luminescent bacterium |
PAA Workshop -Harmony, Overlord and the S-LAB automated plate handler - a powerful combination 11:30 (60 mins) Harmony™ is an easy to use, configurable user interface that allows the control of a small or large system. S-LAB™ is a small footprint, reliable plate handler that supplies microplates from a stack, rack, hotel or incubator. Overlord™ allows control of over 300 instruments with the ability to delid, regrip and process barcodes. PAA have combined these technologies to provide the perfect solution to low cost automation of most instruments. Come to the Overlord User Group meeting at ELRIG Drug Discovery 2018 to discover how S-LAB can automate your lab quickly and cost effectively.” |
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| 11:45 | Chemistry Innovations Platinum Suite 1 How the chemical design and synthesis of linkers used in antibody drug conjugates drives the success of ADC drug development. 11:45 (30 mins) Mark Frigerio , Abzena |
Innovations in cellular HTS and compound profiling Platinum Suite 2 Cellular thermal shift assays in high throughput: a 1536-well cellular target engagement assay for drug discovery 11:45 (30 mins) Lorena Kallal, GlaxoSmithKline |
Anti-infectives & Rare Diseases Platinum Suite 3 Economic models to incentivise antibacterial drug R&D 11:45 (30 mins) Ursula Theuretzbacher, Center for Anti-infective Agents |
11:45 | New IncuCyte applications: Multi-spheroids and Cell-by-Cell analysis 11:45 (25 mins) Tim Dale - Sartorius |
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| 12:10 | 12:10 | Concluding remarks 12:10 (5 mins) |
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| 12:15 | Merck Life Science Innovative Tools in Medicinal Chemistry and Retrosynthetic Pathway Design by Merck. PRESENTER - Hugo Viana ABSTRACT - Sigma-Aldrich, now part of MERCK, is the market leader in Chemical Synthesis, by p...[More] |
Pelago Bioscience AB Why CETSA®HT will Accelerate your Drug Discovery Program PRESENTER - Michael Dabrowski |
Labcyte Inc. Combining Echo Liquid Handler with high-resolution imaging for exploiting host-directed immunomodulatory therapies PRESENTER - Aurore Lejeune-Dodge ABSTRACT - A promising approach to halt the increas...[More] |
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| 12:20 | Eurofins Discovery Eurofins Pharma Discovery Services – a Contract Innovation Organisation PRESENTER - Dr Carol Austin, Associate Director Discovery, Eurofins Selcia ABSTRACT - Selcia is a leading provider of contract r...[More] |
LGC - ATCC Physiologically relevant models to support the development and evaluation of high-throughput screening assays PRESENTER - Dr Nirmal Perera |
Cisbio HTRF Assays + Reagents for anti-infectives + Rare Diseases Research PRESENTER - Louise Affleck, PhD ABSTRACT - Cisbio has developed easy to use, robust + reliable HTRF assays for anti-infectives + Rar...[More] |
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| 12:25 | I&L Biosystems UK LTD Surface Plasmon Resonance Microscopy for Cell Membrane Proteins PRESENTER - Dr Michael Palmowski ABSTRACT - Surface Plasmon Resonance (SPR) is a widely used label-free detection technique for studying...[More] |
INTEGRA Bioscience Ltd Assist Plus PRESENTER - Sharon Barnard ABSTRACT - INTEGRA has developed the ASSIST PLUS pipetting robot to streamline routine pipetting tasks at an affordable price. Using INTEGRA electronic fixed and...[More] |
Bio-Rad Measuring genome editing efficiency using droplet digital PCR PRESENTER - Steve Elliston ABSTRACT - CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and its associated endonuclease C...[More] |
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| 12:30 | Lunch & Poster Sessions | 12:30 | CamBioScience hands-on training courses overview: 12:30 (90 mins) Find out about the various topics, locations, and instructors. You can join the priority list for our future editions and suggest new topics via our online form accessible from your wifi device on the day. - How to create and take personalised training courses online thanks to Artificial Intelligence - DD18 competition to win a free ticket at our next conference: Share the conference page on social media using the conference hashtag revealed on the day. The most interactive post will win a free ticket to our “Development of the Dopaminergic System: From Stem Cells to Circuits” conference held in Crete on 13-14-15 May 2019. The competition starts on the first day of DD18 and end on Christmas Day. |
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| 1:15: | 1:15: | Are We Nearly There Yet? Past Present and Future of Sample Management 13:15 (60 mins) Tecan and Titian will be presenting their long standing partnership in software integration combining sample management and laboratory automation. This builds on the historical work to allow Mosaic users to be guided through setting up a run on a Tecan liquid handler. The topics will range from the humble beginnings of the Genesis integration with Mosaic – to the new Fluent® and FluentControl™ updates which enable the combined software to deliver high capacity and outstanding speed. The platform provides excellent precision, throughput and walkaway time with live a inventory updates. Also to be discussed will future directions to further enable both companies to make it easy to get more done, more confidently and hence support scientists in delivering life-changing research. SPEAKERS: Kevin Moore – introduction and host: Head of Markets and Applications · Tecan Toby Winchester: Automation Product Manager, Business Application Consultant Team Leader · Titian Jason Meredith: Head of Software Product Management · Tecan |
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| 1:55: | SiLA Workshop - Closing the loop in the
Lab using Artificial Intelligence 13:55 (5 mins) Artificial Intelligence (AI) tools are starting to become established in pharmaceutical research and life sciences more generally - with some 69% of companies in the sector using AI and related techniques. Typical uses include mining images and other large data sets for new insights. The possibility is now emerging to use AI to help plan the next experiment – ‘to close the loop’ – for faster and better results. This workshop brings together experts in the lab, and AI to look at closing the loop with AI for two applications: Screening and Chemical synthesis. We will aim to address the following questions: What is possible now? What have the experiences been? What are the pitfalls? And finally, (and perhaps most important!) how can I benefit? Join us for an interactive workshop session, led by industry experts, where we will present use cases and overviews from a range of Scientists. There will be plenty of time for questions and debate as well as presentations on innovative developments in the field. |
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| 2:00 | Chemistry Innovations Platinum Suite 1 Discovery of AZD4573, a potent and selective inhibitor of CDK9 that enables transient target engagement for the treatment of haematological malignancies. 14:00 (30 mins) Bernard Barlaam, AstraZeneca |
Innovations in cellular HTS and compound profiling Platinum Suite 2 Efficiently identifying and characterizing HTS hits with imaging biosignatures 14:00 (30 mins) Steffen Jaensch, Janssen Pharmaceutica |
Anti-infectives & Rare Diseases Platinum Suite 3 An academic entrepreneur’s thoughts about drug discovery where reductionism bumps up against biological complexity and drug promiscuity: generating meaningful targets for intractable disease conditions. 14:00 (30 mins) Steven Zimmer, MitoDys Therapeutics |
BPS Session Platinum Suite 4 Current progress and future opportunities in the development of Nav1.7 blockers for the treatment of pain 14:00 (30 mins) Zahid Ali, Mundipharma Research and Development Natural and engineered genetics for new pain target discovery. 14:30 (30 mins) Alex Gutteridge, GSK Mechanisms based approaches to novel analgesic development: what are the alternatives to opioids for chronic pain? 15:00 (30 mins) Victoria Chapman, University of Nottingham |
Medicinal Chemistry/new small Molecules 14:00 (10 mins) Introduction and scene setting Patrick Courtney (Director, SiLA) |
2:00 | EARLY CAREER PROFESSIONALS
Careers in Drug Discovery: Where to next? 14:00 (60 mins) Are you a post-doc, postgraduate, early career researcher or professional (ECP) scientist looking to start or build your career in drug discovery? If so, understanding the wide array of opportunities and career paths for you beyond academia, and how to make that step, is critical to your success.We invite you join us at our ECP panel discussion event at ELRIG DD 2018, Europe’s largest free to attend Drug Discovery conference. Listen to panelists as they discuss and share their experiences and personal stories in making this transition Increase awareness of different roles and career paths in the drug discovery industrial community Learn more about career and professional development support available to you Meet other ECP scientists & expand your network Prepare for the next exciting step in your career! Facilitator: Dr Clare Viney (CEO, CRAC Vitae) Panelists: Dr David Brierley (Cell Biology Team Leader, GlaxoSmithKline) Dr Andrew Whale (Senior Scientist/Manager, ImmunoCore) Supa Begum (Technical Sales Consultant, Miltenyi Biotech) Dr Clare Russell (MD Biostrata) |
Short live introduction to CRISPR genome editing 14:00 (90 mins) - Digital lecture on “CRISPR Design & Strategy” on our AI-Learning platform OBRIZUM®, by world-leading experts Dr Oliver Baker (King’s College London) and Dr Ben Davies (University of Oxford) - followed by “Check your knowledge” interactive session! By taking part, you can win a free ticket to attend our upcoming 2-Day Hands-On “CRISPR Genome Editing: Design & Strategy” Course on 6-7 December 2018 at Seoul National University, South Korea. Dr Oliver Baker and Dr Ben Davies will be on your instructor team! |
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| 2:10: | Activity-directed synthesis: a platform
for bioactive molecular discovery
Adam Nelson (Rosalind Franklin
Institute/Leeds University) 14:10 (20 mins) |
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| 2:30: | Poster Spotlight - Poster 69 - Linos Lazarides 14:30 (15 mins) The Discovery of a Potent and Orally Bioavailable Macrocyclic Cyclophilin Inhibitor Based on the Structural Simplification of Sanglifherin A |
FORMULATRIX Reaction Miniaturisation with Mantis and Tempest Patented Microdiaphragm Dispensers PRESENTER - Peter Djali ABSTRACT Dispensing low volumes with high accuracy and minimal dead volume is essential for ...[More] |
Poster Spotlight - Poster 68 - Dr Artur Yakimovich 14:30 (15 mins) DeepInfectome: Convolutional Neural Network Approach to Systems Biology Dataset Rediscovery |
Accelerating drug discovery through
automation
Garry Pairaudeau (AstraZeneca) 14:30 (20 mins) |
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| 2:35: | Poster Spotlight - Poster 48 - Bomi Jung 14:35 (10 mins) High density assessment of drug distribution profiles in cultured cells |
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| 2:45: | Chemistry Innovations Platinum Suite 1 Biocatalysis in Drug Discovery 14:45 (30 mins) Doru Roiban, GlaxoSmithKline |
Innovations in cellular HTS and compound profiling Platinum Suite 2 Implementation of a patient derived disease model using human iPSC for drug screening 14:45 (30 mins) Magda Bictash, UCL |
Anti-infectives & Rare Diseases Platinum Suite 3 The case for combination antimicrobial chemotherapy for AMR 14:45 (30 mins) William Hope, University of Liverpool |
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| 2:50: | ROAR: The Centre for Rapid Online
Analysis of Reactions
Mimi Hii (Imperial College/ROAR) 14:50 (20 mins) |
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| 3:10: | Discussion 15:10 (20 mins) |
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| 3:15: | Malvern Panalytical PRESENTER - Maria Walton |
Beckman Coulter GmbH We are programmed just to do, anything you want us to. PRESENTER - Dr. Ewan Grant, Sales Manager Life Science Automation and Genomics, Northern Europe, Beckman Coulter UK Ltd ABSTRACT - Although hardw...[More] |
Horizon Discovery Horizon’s cellular HTS platform for the identification of beneficial combinations in rare disease PRESENTER - David Sorrell, PhD; HTS Platform Lead ABSTRACT -Horizon is a provider of cellular HTS serv...[More] |
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| 3:20: | Tecan UK Ltd One size does not fit all PRESENTER - Guido Cimoli ABSTRACT - When it comes to laboratory automation a very common understanding is that all what is needed is a “robot” performing some tasks instead o...[More] |
Hamilton Sales & Service UK Ltd. A fully automated QC workflow for therapeutic proteins PRESENTER - Dr. Carsten Mang ABSTRACT The numbers of therapeutic protein projects are increasing year by year. This requires increased efficiency...[More] |
BioIVT Vaccine Efficacy studies PRESENTER - Amanda J Woodrooffe, PhD ABSTRACT - Vaccines are the most cost-effective medical intervention for viral, bacterial, and parasitic infections, saving millions of li...[More] |
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| 3:25: | Aptamer Group Limited OptimersTM: the next step in aptamer development PRESENTER - Dr David Bunka ABSTRACT - - At Aptamer Group, we are dedicated to continually improving our service offering, to identify the best performi...[More] |
Promega UK Ltd New bioluminescent tools and approaches for physiologically relevant cellular HTS assays. PRESENTER - Dr Craig Malcolm. ABSTRACT -Robust assay tools and approaches are essential for the successful exe...[More] |
LGC - ATCC |
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| 3:30: | Coffee | 3:30: | How to create and take personalised training courses online thanks to Artificial Intelligence 15:30 (30 mins) |
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| 4:00 | Chemistry Innovations Platinum Suite 1 Capture Compound® Mass Spectrometry: On- and Off-Target Deconvolution 16:00 (30 mins) Andrew Cridland, Charles River Using PROTACs as probes to study intracellular target engagement against proteins with unknown function 16:30 (30 mins) Matthew Cheeseman, The Institute of Cancer Research |
Innovations in cellular HTS and compound profiling Platinum Suite 2 Organoids: Predicting clinical responses in an in vitro model 16:00 (30 mins) Robert Vries, Hubrecht Organoid Technology Biomicrofabrication of Cellular Interfaces and Models 16:30 (30 mins) Cristina Bertulli, University of Cambridge |
Anti-infectives & Rare Diseases Platinum Suite 3 Multi-targeting to reduce bacteria resistance 16:00 (30 mins) Chris Dowson, University of Warwick Combination drugs for safe treatment of children with rare cancers 16:30 (30 mins) David Brown, Healx Ltd |
BPS Session Platinum Suite 4 Delta opioid receptor agonists; potential in chronic pain therapy 16:00 (30 mins) David Kendall, PharmNovo AB/UK Altered pain processing in a rat model of negative affective state: a role for the endogenous cannabinoid and opioid systems 16:30 (30 mins) David Finn, NUI Galway |
Screening -
Adalab closed loop and underpinning
ontologies
Larisa Soldatova (Goldsmiths College/
ADALab) 16:00 (20 mins) |
4:00 | Short live introduction to Organoid technology 16:00 (60 mins) - Digital lecture on “Cerebral Organoids” on our AI-Learning platform OBRIZUM®, by world-leading expert in the field, Dr Madeline Lancaster (University of Cambridge) - followed by “Check your knowledge” interactive session! By taking part, you can win a free ticket to attend our upcoming 2-Day Hands-On “Cerebral Organoids: Establishment, Culture & Manipulation” Course on 22-23 October 2018 at Homerton College, Cambridge UK. Dr Madeline Lancaster and her lab will be your instructors! |
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| 4:20: | Smarter screening, how to leverage AI to ‘close the loop’
Kevin Teburi, Genedata
16:20 (20 mins) |
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| 4:40: | Lundbeck’s transition to integrated
drug discovery informatics platform
Plamen Petrov (Lundbeck Pharma) 16:40 (20 mins) |
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| 5:00 | Drinks reception & Posters | Enabling ML and AI through a
Standards-based Data Pipeline
Burkhard Schaefer, (BSSN Software /
SiLA Board of Directors) 17:00 (30 mins) End of workshop |
5:00 | Come chat to us: 17:00 (90 mins) We will discuss your training requirements, share resources, and you can join the priority lists for any of our future courses. Have an idea for a particular training course, just come to the training zone to start a collaboration. |
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| 5:15: | 5:15: | EARLY CAREER PROFESSIONALS
Careers in Drug Discovery: Network like a Boss 17:15 (60 mins) Are you a post-doc, postgraduate, early career researcher or professional (ECP) scientist looking to start or build your career in drug discovery? If so, building and managing your network of contacts is critical to your success. We invite you join us at our ECP speed networking event at ELRIG DD 2018, Europe’s largest free to attend Drug Discovery conference Speed meet 1:1 with selected representatives across the drug discovery community, including pharma, biotech, CROs, non-for profit and more Learn how to network effectively Increase your awareness of roles and career paths in industry, academia and beyond Expand your list of contacts and potential future employers Open new doors to an exciting future |
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| 6:45: | 6:45: | 6:45: | |||||||||||
| 6:50: | 6:50: | 6:50: | |||||||||||
| 6:55: | 6:55: | 6:55: | |||||||||||
| 7:00 | 7:00 | 7:00: |
