BSP Spring Meeting 2019
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The Plasmodium LAP complex affects crystalloid biogenesis and oocyst cell division

Mon15  Apr05:30pm(15 mins)
Renold C2
dr sadia saeed


S Saeed1
1 Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT., UK


Malaria parasite oocysts located on the mosquito midgut generate sporozoites by a process called sporogony. Plasmodium berghei parasites express six LCCL lectin domain adhesive-like proteins (LAPs), which operate as a complex and share localisation in the crystalloid – an organelle found in the ookinete and young oocyst. Depletion of LAPs prevents crystalloid formation, increases oocyst growth, and blocks sporogony. LAP4 is also one of the member of LAP protein family and its mutant has abnormal crystalloid biogenesis and produces oocysts that display reduced growth and premature sporogony. These findings provide evidence for a role of the LAP complex in regulating oocyst cell division via the crystalloid.

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