BSP Spring Meeting 2019
Schedule : Back to dr sadia saeed

The Plasmodium LAP complex affects crystalloid biogenesis and oocyst cell division

Mon15  Apr05:30pm(15 mins)
Where:
Renold C2
Speaker:
dr sadia saeed

Authors

S Saeed1
1 Department of Pathogen Molecular Biology, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT., UK

Discussion

Malaria parasite oocysts located on the mosquito midgut generate sporozoites by a process called sporogony. Plasmodium berghei parasites express six LCCL lectin domain adhesive-like proteins (LAPs), which operate as a complex and share localisation in the crystalloid – an organelle found in the ookinete and young oocyst. Depletion of LAPs prevents crystalloid formation, increases oocyst growth, and blocks sporogony. LAP4 is also one of the member of LAP protein family and its mutant has abnormal crystalloid biogenesis and produces oocysts that display reduced growth and premature sporogony. These findings provide evidence for a role of the LAP complex in regulating oocyst cell division via the crystalloid.

Hosted By

British Society for Parasitology (BSP)

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