High Productivity and Process Economy in GxP Applications with the Octet® Platform


P Khandelwal,1; D Apiyo,1; N Salim1; S Kumaraswamy1; S Knowling1
1 Sartorius, UK


Utilizing the label-free optical technique of Bio-Layer Interferometry (BLI), the Octet® BLI platform provides real time analysis of biomolecular interactions. It relies on the robust and easy to use Dip and Read format, which provides faster time to results relative to technologies like ELISA and SPR. It also operates in a fluidics-free format thereby minimizing the complexity in analyte detection by fluidics-based technologies like SPR or Grating Coupled Interferometry (GCI). It provides highthroughput analysis, with the capability of analyzing up to 96 samples simultaneously, thereby increasing analytical productivity. It has a high tolerance to a diverse array of sample types, making it compatible with in-process testing during drug substance manufacturing. In addition, samples analyzed on an Octet® system can be reused for other analysis, minimizing depletion of precious samples and maximizing process economy. In this poster, we will describe multiple ways in which the Octet® platform is well suited for GxP and QC applications.

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