Implementing fully automated kinase inhibitor characterization using a robotic system


D Thomas1; T Fleming1; M Bittner1
1 Arctoris Ltd, UK


The family of Janus kinases (JAK) play an important role in several disease areas, including oncology, immunology/ inflammation and longevity, and have also been identified as potential therapeutic targets for COVID-19. Arctoris deployed its automated drug discovery platform, Ulysses, to generate a comprehensive dataset on 24 small molecules against all four members of the JAK family. In under 100 h, the platform completed an extensive experimental program resulting in a large, structured dataset revealing a diverse set of pharmacologically distinct profiles.

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