Point of Care Thawing of Cryopreserved Cell Therapies

Fri14  Oct03:15pm(30 mins)
Dr Stuart Milne


Asymptote is collaborating with the Cell
and Gene Therapy Catapult (CGTC) to create products that are designed to
improve the final processing step of many Advanced Therapy
Medicinal Products
(ATMP) processes; thawing of the cryopreserved
material near to the patient. The thawing step is of critical importance to the
efficacy and quality of the therapy, but is currently poorly controlled (e.g.
use of water baths) and there is a lack of academic understanding surrounding process
conditions and their impact on the underlying biology.

Asymptote and the CGTC have spoken to and
engaged numerous stakeholders (e.g. Cell and Gene Therapy companies, clinics,
regulatory bodies) and have performed numerous experiments (both thermodynamic
and biological) to build deep understanding of how the thawing process is
currently handled in the clinic, and what could be done to improve it.

In this talk Asymptote will both introduce
the equipment that they are currently designing and testing, and share
biological results obtained during the development phase of the new thawing system

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