Novel T cell-based tools in diagnosis and management of microbial infections

Fri14  Oct02:45pm(30 mins)
Where:
HALL 1B
Speaker:
 Ludwig Deml

Discussion

T cell diagnostics is an emerging field addressing essential clinical
needs relevant to transplantation medicine, infectiology and autoimmunity. Lophius
has developed innovative technology platforms (T-activation® and Reverse T cell
Technology - RTT) permitting a sensitive quantification of functional
pathogen-reactive effector and memory T cells. The T-activation® technology,
based on a proprietary antigen formulation, was transferred into the development
of a highly sensitive, standardized, reliable and user-friendly IFN-γ ELISpot-based
immune monitoring tool, leading to the development of a self-declared CE-marked
IVD kit (T-Track® CMV) according to IVD directive 98/79/EC. T-Track® CMV allows
the sensitive and
reliable monitoring of functional impairment of T cell-mediated immunity in
immunocompromized patients at risk of CMV reactivation and CMV-related clinical
complications. Two completed and one on-going prospective multicenter clinical
validation studies in solid organ and allogenic hematopoietic stem cell
transplant recipients established correlates between T-Track® CMV results and clinical outcome, thus
demonstrating the principal suitability of T-Track® CMV in
assisting clinicians to evaluate the risk of CMV disease and to guide therapeutic choices. An
ongoing interventional study in a cohort of recipients of solid organ
transplantation with high risk of CMV-related complications aims to assess
health-economic benefit in addition to clinical outcome.

Hosted By

ELRIG

The European Laboratory Research & Innovation Group Our Vision : To provide outstanding, leading edge knowledge to the life sciences community on an open access basis
Event Logo Find us on Facebook Follow us on Twitter

Get the App

Get this event information on your mobile by
going to the appstore or google play and search for 'elrig'
Eventflo Home
copyright ELRIG, eventflo.co.uk, Labhoo Ltd 2003-2022