Synthetic Promoters: Precision in Gene Control

Fri14  Oct10:00am(30 mins)
 Michael Roberts


Synthetic Biology is a relatively
new discipline, having leapt onto the scene over a decade ago, as a means to
introduce engineering principles to improve and exploit bio-based processes.
The vision is that genetic parts can be standardised and taken “off-the-shelf”
to build complex biological systems to improve upon various industrial
processes. The key to this vision is being able to identify parts that perform
in a predictable fashion in any given biological system, and this remains its
greatest challenge. At Synpromics we have developed a systematic way in which
to construct synthetic promoters that mediate unprecedented control of gene
expression. By adopting complex bioinformatics analysis of functional genomics
datasets we are able to create promoters that are active under pre-defined
transcription profiles. The approach is broadly applicable across all
eukaryotic organisms and we have employed it across a diverse array of
applications. Here we present data on promoters that mediate predictable expression
in different human cell types and present in vivo data demonstrating specific
and efficacious gene expression. The promoters add to the gene therapist’s
toolbox and can be used to enable the design of more effective gene transfer
vectors to enhance the treatment of genetic disease.

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