Poster
96

EFFICIENT AND SCALABLE GMP-GRADE CULTURE MEDIA SYSTEM FOR RAPID CARDIOMYOCYTE DIFFERENTIATION OF PLURIPOTENT STEM CELLS IN HUMAN DISEASE RESEARCH

Discussion

Simple and robust derivation of spontaneously contracting cardiomyocytes derived from human pluripotent stem cells (hPSCs) would provide a valuable source of cells for basic research into cardiac biology and mechanisms of heart disease as well as applied studies in pharmacological drug discovery and toxicity screening. Currently a number of protocols exist for inducing embryoid bodies (EB) suspension or monolayer cultures of hPSC to differentiate into cardiomyocyte (Iglesias-Garcia et al 2013; Priori et al 2013). These cardiomyocyte differentiation protocols have led to varying results and differing purity levels of cardiomyocytes. To enable consistent differentiation of hPSCs, we developed a simplified cardiomyocyte differentiation media system, consisting of three ready-to-use components. This easy to use cardiac differentiation system is designed for monolayer hPSC affording flexible culture formats and a scalable workflow enabling generation of large numbers of consistent, spontaneously active cardiomyocytes.

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