Programme : Back to Dr Violeta Niculescu
Poster
68

New metallic complexes as a potential drugs for urease activity inhibition

Discussion

Inhibition of the enzymes remains an important area of pharmaceutical research, because these studies can led to the discovery of useful medicines for various diseases.
Hyper-gastric anemia mechanism associated with Helicobacter pylori infection is still unclear. It can be an effect of the ammonia produced in the battery in the antral epithelium surface region. Helicobacter pylori is remarkable for its high urease activity which hydrolyzes urea to ammonia and carbon dioxide. As a result of this, patients with this type of infection have low concentrations of urea and elevated ammonia concentrations in gastric juice. Ammonia is a strong base and thus it can prevent the physiological inhibition of gastric acid release.
Urease inhibitors have recently attracted attention as a potential new anti-ulcer drugs. In this respect, this study presents a new transition metal complexes with naphthoquinone ligand supported on or not on nanostructured oxides, which were tested on the urease activity. The results showed that one of the metal complex has a high inhibitor effect on urease activity. On the other hand, the complex immobilized on nanostructured SBA-15 and amino-SBA-15 presents a lower inhibitor effect, this conclusion being just an apparent one, because, although the effect on urease activity decreases, once the complex is immobilized, its secondary effects after administration might be reduced.
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