Programme : Back to Dr Valerie Legris

Liver cancer cells grown in 3D in the Mimetix scaffold regain a primary-like phenotype


Primary human hepatocytes are the gold standard in in vitro toxicology studies. However, their limited availability, short life span, inter-donor variation and cost are important limitations for screening assays. Our work strongly indicates that HepG2 liver carcinoma cells grown in the Mimetix scaffold could be used instead to study drug-induced hepatotoxicity. HepG2 cells cultured in the 3D Mimetix tissue culture plate display a primary-like phenotype. They maintain basic functionality (urea and albumin production) and re-acquire metabolic activity of both phase I (CYP450) and phase II enzymes (SULT and UGT) activity over 28 days.
Add to favourites

Hosted By
The European Laboratory Research & Innovation Group Our Vision : To provide outstanding, leading edge knowledge to the life sciences community on an open access basis
Event Logo Find us on Facebook Follow us on Twitter

Get the App
Get this event information on your mobile by
going to the appstore or google play and search for 'elrig'
iPhone App
Android App
Eventflo Home
copyright ELRIG, eventflo, Labhoo Ltd 2018