Programme : Back to Mrs Helen Boyd
Poster
13

Hunting for hits for E3 ligases

Discussion

E3 ligases are interesting drug targets for a number of different disease indications, however there are a number of challenges in working with these targets. IDOL (inducible degrader of the LDL receptor (LDLr)) is a cytosolic E3 ligase which catalyses the ubiquitination of LDLr and targets the receptor for degradation in the cell. Based on internal knock out mouse data an inhibitor of IDOL will increase LDLr levels and subsequently decrease circulating LDL-cholesterol .

Within discovery sciences we design screening strategies and cascades specific for each target and to complement this we have established a number of hit identification approaches. In the case of IDOL multiple hit finding approaches have been executed using both cell based and binding assays. In addition secondary in vitro assays have enabled hit evaluation and characterization in order to understand interaction with the target and biological effects.
Programme
Add to favourites

Hosted By
ELRIG
The European Laboratory Research & Innovation Group Our Vision : To provide outstanding, leading edge knowledge to the life sciences community on an open access basis
Event Logo Find us on Facebook Follow us on Twitter

Get the App
Get this event information on your mobile by
going to the appstore or google play and search for 'elrig'
iPhone App
Android App
www.myeventflo.com/1791
Login
Eventflo Home
copyright ELRIG, eventflo, Labhoo Ltd 2018