Programme : Back to Damian Young

Using Diversity-Oriented Synthesis to Enable Fragment-Based Lead Discovery

Wed2  Sep09:15am(45 mins)
Where:
Pattingham
Keynote Speaker:
 Damian Young

Discussion

Fragment-Based Lead Discovery (FBLD) has emerged as a powerful strategy for the generation of therapeutic lead compounds. We are applying Diversity-Oriented Synthesis (DOS) as a means of expanding the fragment chemical space. Additionally, the DOS paradigm allows for rapid fragment modification to produce high-affinity binders. Our diverse fragment collection will be screened against a swath of biologically interesting disease targets. The lecture will detail the various aspects of applying DOS to FBLD.
Programme
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