The new St Thomas' Hospital polarised vs. hyperkalaemic St. Thomas’ cardioplegia: improved myocardial protection in pigs using cold blood cardioplegia

Mon13  Mar02:00pm(10 mins)
Meeting Room 3A


D Santer4; A Kramer4; A Kiss4; K Aumayr1; S Hallström3; H Fallouh2; S Skalicky5; B Podesser3; D Chambers2
1 Clinical Institute for Pathology, AKH Wien, Medical University of Vienna, Austria;  2 Guy's and St Thomas' NHS Foundation Trust, UK;  3 Institute of Physiological Chemistry, Center for Physiological Medicine, Medical University of Graz, Austria;  4 Ludwig Boltzmann Cluster for Cardiovascular Research at the Department for Biomedical Research, Medical University of Vienna,, Austria;  5 TAmiRNA GmbH, Vienna, Austria


Increasingly, patients undergoing cardiac surgery are elderly and sicker, therefore, novel and more effective cardioprotective regimes are warranted. Maintaining cardiac arrest at a membrane potential closer to the resting potential (with ‘polarising’ cardioplegia) improved cardioprotection compared to the conventional high potassium based ‘depolarising’ cardioplegia in small animal (rodent) in crystalloid preparation. This study, in a large animal (pig) model of cardiopulmonary bypass (CPB), compared the cardioprotective efficacy of the new blood-based St Thomas’ Hospital Polarising cardioplegia (STH-Pol): esmolol, adenosine, magnesium) to conventional (depolarising hyperkalaemic) blood-based St Thomas’ Hospital cardioplegia (STH2).


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